The following table shows the content covered by the EXACT and E-RS. This information is also provided in Leidy et al. 2014. (Note that reference to the EXACT-RS in the published paper pre-dates the name change.)
For a copy of the instrument(s), please contact [email protected].
| Symptom Construct | Item-level Construct1 | Item Number |
| Breathlessness | ||
| Breathless today2 | 7 | |
| Breathless with activity3 | 8 | |
| Short of breath – personal care3 | 9 | |
| Short of breath – indoor activity3 | 10 | |
| Short of breath – outdoor activity3 | 11 | |
| Cough and Sputum | ||
| Cough frequency3 | 2 | |
| Mucus quantity3 | 3 | |
| Difficulty with mucus3 | 4 | |
| Chest Symptoms | ||
| Congestion2 | 1 | |
| Discomfort2 | 5 | |
| Tightness2 | 6 | |
| Additional Attributes | ||
| Tired or weak2 | 12 | |
| Sleep disturbance2 | 13 | |
| Scared or worried2 | 14 |
a All 14 items are administered as a daily diary; The EXACT total score uses all 14 items with logit scoring transformed to a 0 to 100 interval-level scale; E-RS scoring uses only the respiratory symptom items, with subscales for breathlessness, cough and sputum, and chest symptoms. E-RS scores are based on summation to yield ordinal-level scales.
1 Items are worded as simple questions. Recall: “Today”. Patients are asked to complete diary every evening before they go to bed. The formatted instrument is available through [email protected].
2 5-point scale, Not at all to Extremely
3 5-point scale – other
The EXACT® was developed under the EXACT-PRO Initiative®, a multi-year, multi-sponsor project involving experts in pulmonary medicine, instrument development, and drug development regulatory issues, dedicated to the development of a single, standardized instrument for evaluating the effects of treatment on acute exacerbations of COPD.
The EXACT®, E-RS®, and all related materials are owned by Evidera and are subject to Evidera’s Legal Disclaimer.
